Ryan had an allergic reaction to platelets last month and
now has to be pre-medicated with Benedryl before he receives blood products. He
was in such a great mood this morning and was having a good time playing with
the Child Life Specialist while waiting for his platelets. Then, the IV
Benedryl kicked in and everyone in the room could just see the immediate change.
He was clearly mad that it was making him sleeping and he couldn’t play
anymore. About 5 minutes later, he was out.
Not much has changed in the last month. Ryan continues to
need platelets about every 7-10 days and red blood about once a month (the life
of a platelet is generally 6 days and a red blood cell lives for about 35
days). He has another bone marrow biopsy tomorrow to see if there are any
changes in his marrow, such as a change in cellularity. My main concern at this
point would be the discovery of hypercellular marrow (a marrow filled with too
many stem cells that are not working properly), which could indicate a rapid
progression from Aplastic Anemia (not enough cells) to Myelodysplastic syndrome
(MDS).
We are also still waiting on the results of the more detailed genetic testing. I received a little more clarification regarding what they are looking at currently, and how the original genetic tests were different. The genetic testing done back in November looked at the DNA level and normally catches the nine most common reasons for genetic bone marrow failure. In January, they went one level further and did Cytogenic testing to look at Chromosomes. In theory, the Cytogenic testing should have revealed any genetic issues that would contribute to MDS. Now, they are looking at individual genes to see if they can identify any mutations. We are waiting on the results from three different tests, one of which is a test developed at theUniversity of Washington
We are also still waiting on the results of the more detailed genetic testing. I received a little more clarification regarding what they are looking at currently, and how the original genetic tests were different. The genetic testing done back in November looked at the DNA level and normally catches the nine most common reasons for genetic bone marrow failure. In January, they went one level further and did Cytogenic testing to look at Chromosomes. In theory, the Cytogenic testing should have revealed any genetic issues that would contribute to MDS. Now, they are looking at individual genes to see if they can identify any mutations. We are waiting on the results from three different tests, one of which is a test developed at the
We are still on target to go back to SCCA and start the
transplant process on April 2nd.
Not much has changed in the last month. Ryan continues to need platelets about every 7-10 days and red blood about once a month (the life of a platelet is generally 6 days and a red blood cell lives for about 35 days). He has another bone marrow biopsy tomorrow to see if there are any changes in his marrow, such as a change in cellularity. My main concern at this point would be the discovery of hypercellular marrow (a marrow filled with too many stem cells that are not working properly), which could indicate a rapid progression from Aplastic Anemia (not enough cells) to Myelodysplastic syndrome (MDS).
We are also still waiting on the results of the more detailed genetic testing. I received a little more clarification regarding what they are looking at currently, and how the original genetic tests were different. The genetic testing done back in November looked at the DNA level and normally catches the nine most common reasons for genetic bone marrow failure. In January, they went one level further and did Cytogenic testing to look at Chromosomes. In theory, the Cytogenic testing should have revealed any genetic issues that would contribute to MDS. Now, they are looking at individual genes to see if they can identify any mutations. We are waiting on the results from three different tests, one of which is a test developed at theUniversity of Washington
Not much has changed in the last month. Ryan continues to need platelets about every 7-10 days and red blood about once a month (the life of a platelet is generally 6 days and a red blood cell lives for about 35 days). He has another bone marrow biopsy tomorrow to see if there are any changes in his marrow, such as a change in cellularity. My main concern at this point would be the discovery of hypercellular marrow (a marrow filled with too many stem cells that are not working properly), which could indicate a rapid progression from Aplastic Anemia (not enough cells) to Myelodysplastic syndrome (MDS).
We are also still waiting on the results of the more detailed genetic testing. I received a little more clarification regarding what they are looking at currently, and how the original genetic tests were different. The genetic testing done back in November looked at the DNA level and normally catches the nine most common reasons for genetic bone marrow failure. In January, they went one level further and did Cytogenic testing to look at Chromosomes. In theory, the Cytogenic testing should have revealed any genetic issues that would contribute to MDS. Now, they are looking at individual genes to see if they can identify any mutations. We are waiting on the results from three different tests, one of which is a test developed at the
We are still on target to go back to SCCA and start the
transplant process on April 2nd.
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